Scientist Cryo-Electron Microscopy

  • Salary: Competitive
  • REF Number: 00055481
  • Consultant: Adrien Guimard
  • Contact: 0041 (0) 800 106 106
  • Date Published: 03.05.2023
  • Closed Date: 26.06.2023
  • Sector:
  • Location: Aargau,
  • Discipline:

QLS are recruiting for a Cryo EM Scientist to join a Biotech Start-up based in Aargau on a permanent basis.


The company is a rapidly growing biotech company focusing on solving structures of membrane protein drug targets for the discovery and optimization of next-generation medicines. They have an integrated platform for membrane protein biochemistry, biophysics and structural biology, including X-ray crystallography and cryo-EM. Their team combines specialized knowledge in protein science, pioneering technologies in structural biology and expertise in ligand design and characterization. This position is an excellent opportunity to join a young and exciting company engaged in cutting-edge applied research.

Key Responsibilities:

  • Establish protocols for membrane protein vitrification using conventional and emerging technologies
  • Perform membrane protein sample vitrification optimization making use of tight interaction with membrane protein purification experts and own expertise in protein purification and formulation technologies
  • Cryo-EM grid quality inspection, for assessment of optimal ice quality and particle distribution using our in-house screening electron microscope
  • Collect and determine structures to investigate apo and potential drug ligand molecule interaction in high resolution cryo-EM structures
  • Contribute to the further development of the EM capabilities by keeping up to date with the new and emerging scientific innovations
  • Analyse, report and present data to project teams, clients or supervisors in an organized and dynamic way, enabling efficient project decision making
  • As EM project leader, be responsible and have the scientific merits to coordinate, organize as well as perform designated projects
  • Direct work interaction and collaboration with a multi-disciplinary team of scientists


  • Highly motivated PhD Scientist with an open and positive mindset.
  • 5+ years of post-doc experience or 2-3 years of industry experience in cryo-EM laboratories, operating experience for 120 kV, 200 kV and 300 kV microscopes for EM data collection in mandatory (Proven record of successful own practical experience in EM is mandatory)
  • Experienceworking with ABC transporter drug targets
  • Hands-on experience in biochemistry and cryo-electron microscopy (protein purification, sample vitrification, sample screening and electron microscope operation) is mandatory.
  • Proficiency with cryo-EMsoftware packages (CryoSPARC, RELION, EMAN2, Coot, Phenix, etc…) is highly recommended.
  • Excellent communication and presentation skills as well as fluency in English are essential.
  • Knowledge on membrane protein formulation optimization (nanodiscs, amphipols, etc…) and experience with various vitrification systems is an advantage
  • Proven ability to work in a collaborative environment, coordinate complex and time-sensitive experiments with multiple partners (colleagues, facilities, clients, etc..).


For more information or to apply for this position, please contact Adrien on 0041 (0) 800 106 106 or email Please could you send any correspondence in English. Please quote job reference 55481 in all correspondence.

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