Head of Computational Chemistry

  • Salary: Competitive
  • REF Number: v-156433
  • Consultant: Adrien Guimard
  • Contact: +41 (0) 800 106106
  • Date Published: 08.10.2025
  • Industry: Biotech
  • Location: Villigen, Switzerland
  • Functional Expertise: Other

Principal Scientist, Head of Computational Chemistry, Argau Canton , Switzerland, Permanent job

The company

The company is a rapidly growing biotech company focusing on solving structures of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters) for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression, purification and engineering, and preferential access to synchrotron and free electron laser beamlines for X-ray analysis and cryo-EM facilities, they characterize the interaction of small molecules and biotherapeutics with drug targets in time to impact the discovery of novel therapeutics.

Key tasks and responsibilities

  • Utilize modern molecular modelling methods to support different stages of R&D programs.
  • Collaborate effectively with other functions to advance research discovery projects expeditiously from early target assessment to hit-to-lead and lead optimization.
  • Design, lead and drive computational studies on projects throughout the several discovery phases and ensure execution on agreed deliverables.
  • Set the vision and strategy for computational chemistry.
  • Manage data warehousing for lead discovery projects using CDD Vault to facilitate secure and efficient data management and collaboration.
  • Collaborate with external partners on joint drug discovery projects.
  • Present plans and results internally, including at board level, and externally at conferences.
  • Keep up to date with the latest scientific advances and trends in drug discovery to deliver the next-generation therapies.
Your qualification

  • MSc/PhD in a relevant scientific discipline (Pharmaceutical Sciences, Chemistry, Computational Chemistry) with a solid foundation in molecular modelling built in a pharma/biotech/CRO setting.
  • Expert knowledge in CADD software packages and modern molecular modelling techniques.
  • Sound knowledge in cutting-edge cheminformatic tools, AI/ML-enabled technologies, and in silico drug design, including both structure- and ligand-based methodologies.
  • Passion for drug discovery with a deep understanding of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters).
  • Mastery of all the theoretical and practical principles of medicinal chemistry and drug design.
  • Broad knowledge of biophysical, biochemical, and cell-based assays used in the early stages of the drug discovery process.
  • In depth understanding of multi-parameter optimization and ability to integrate disease biology, ADME/DMPK and toxicology data to solve complex drug discovery problems.
  • Excellent leadership, management, organizational and team-working skills, and a talent to deliver project milestones within the expected time frame.
  • Demonstrated track record of scientific publications.
Benefits

  • You will be working for an innovative company aiming to discover new generation medic
  • You will be working with state-of-art technologies
  • You will be working in a supportive and dynamic team
  • Share options bonus
If you are interested, please send a CV.

It is essential that applicants hold entitlement to work in Switzerland. Please quote job reference 156433 in all correspondence.

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